Long-term hypersensitivity of spinal dorsal horn neurons to heat and mechanical stimulation induced by subcutaneous bee venom injection in anaesthetized rats and cats. The 3rd EFIC Congress (Nice, France), 2000, p208.
Updated: April. 29th, 2006
Summary:
Hao-Jun You
holds Ph.D. degree in Neuroscience from Aalborg University of
Denmark, and Master degree in Physiology from Xi'an Medical University
of P.R.
China.
His principal research interests focus on cell electrophysiology, in
particular
sensory-motor interaction of the spinal cord within pain area.
Ph.D. degree in Neuroscience, Aalborg University,
Denmark
Master degree in Physiology, Xi'an Medical University.
P.R. China
Bachelor degree of Medical Science, North China Coal Mines
Medical College. P.R. China
2-year full time working experience as a physician for
Neurology. Xi'an, P.R. China
Education
Background:
(1) Ph.D. student in
Neuroscience (March 1st, 2000 - February 28, 2003).
Center for Sensory Motor Interaction (SMI), Laboratory for Experimental
Pain
Research, Aalborg University, Denmark
Thesis Title: Sensory-Motor Interaction of the spinal cord dorsal
horn
neuron and spinal withdrawal reflex in rats
Specialize in Neurophysiology, research work were conducted
by electrophysiological
techniques in vivo from both
the peripheral and the central nervous system site. In
particular,
one innovating recording method; simultaneous recordings for spinal
dorsal
horn
neuron activity and single motor unit EMG response from gastrocnemius
muscle were established and developed.
(2) Master
degree in Physiology (September 1996 - July 1999).
Department of Physiology, Xi’an
Medical University. Xi'an, P.R. China
Thesis Title: Role of cerebral cortex in the inhibitory effect of
electro-acupuncture
on the tonic pain response of spinal dorsal horn neurons
Specialized in Neurophysiology, research work were conducted by
electrophysiological
techniques. Formalin and Bee venom animal model was employed in
pain research.
(3) Bachelor
of Medical Science (September 1989-July 1994) (MD).
Faculty of Pediatrics, North China Coal Medical College, TangShan city,
Hebei Province, P.R. China
Specialized in Pediatrics Medicine
Employment History:
Resident physician (July 1994-August 1996), majored in
Neurology.
The Research Institute of Neurology, Xi’an
city, Shaanxi Province. P.R. China
Publications:
Research papers:
1. Hao-Jun
You, Arne Tjølsen, Lars Arendt-Nielsen.
High-frequency conditioning electrical stimulation
evokes supraspinal independent long-term depression but not long-term
potentiation of the spinal withdrawal reflex in rats. Brain Res. 2006
Apr 23; [Epub ahead of print]
2. Hui-Sheng Chen, Jing Lei, Xiang He, Yang Wang, Wei-Wei Wen,
Xue-Zhong Wei, Thomas Graven-Nielsen, Hao-Jun You,
Lars Arendt-Nielsen.
Pivotal involvement of neurogenic mechanism in
subcutaneous bee venom-induced inflammation and allodynia in
unanesthetized conscious rats. Exp Neurol. 2006 Apr 17; [Epub ahead of
print]
3. Hao-Jun You,
Dong-Yuan Cao, Bin
Yuan, Lars Arendt-Nielsen.
Sex differences in the responses of spinal
wide-dynamic range neurons to
subcutaneous formalin and in the effects of different frequencies of
conditioning electrical stimulation. Neuroscience 2006;138: 1299-1307.
7. Hao-Jun You, Carsten Dahl Morch, Lars
Arendt-Nielsen.
Electrophysiological characterization of facilitated
spinal withdrawal reflex to repetitive electrical stimuli and its
modulation by central glutamate receptor in spinal anesthetized rats.
Brain Res. 2004;1009: 110-119.
8. Hao-Jun You, Carsten Dahl Morch, Jun Chen, Lars
Arendt-Nielsen.
Differential antinociceptive effects induced by
a selective COX-2 inhibitor (SC-236) on dorsal horn neurons and spinal
nociceptive withdrawal reflex in anesthetized spinal rats. Neuroscience
2003;121: 459-472.
9. Hao-Jun You, Carsten Dahl Morch, Jun Chen,
Lars
Arendt-Nielsen.
Role of central NMDA vs. non-NMDA receptor on spinal
withdrawal reflex in spinal anesthetized rats under normal and
hyperexcitable
conditions. Brain Res. 2003;981: 12-22.
10. Hao-Jun You, Carsten Dahl Morch, Jun Chen, Lars
Arendt-Nielsen.
Simultaneous recordings of wind-up of paired spinal
dorsal horn nociceptive neuron and nociceptive flexion reflex in rats.
Brain Res. 2003;960: 235-245.
11. Hao-Jun You, Jun Chen, Carsten Dahl Morch, Lars
Arendt-Nielsen.
Differential effect of peripheral glutamate (NMDA,
non-NMDA) receptor antagonists on bee venom induced spontaneous
nociception
and sensitization. Brain Res. Bull. 2002;58: 561-567.
12. Hao-Jun You, Jun Chen.
Differental effects of subcutaneous injection of
formalin and bee venom on response of wide-dynamic range neurons in
spinal
dorsal horn of the rat. Eur. J. Pain 1999;3: 177-180.
13. Hao-Jun You, Bin Yuan and Jing-Shi Tang.
Role of the rat SI cortex in the inhibition of
spinal
nociception transmission produced by electro-acupuncture in tonic pain.
Chin. J. Neurosci. 1999;15: 301-305. (Chinese)
14. Hao-Jun You, Bin Yuan and
Jing-Shi Tang.
The effect of stimulation of cerebral peduncle on
formalin-induced tonic pain response of spinal dorsal horn neurons in
rats.
Chin. J. Neurosci. 2000;16: 37-40.
(Chinese)
15. Hao-Jun You, Hong-Wei
Sun. Basic and
clinical
aspect of GABA in epilepsy. Foreign Medicine: volume of Neurology and
Neurosurgery. 1998;25: 171-174.
(Review in Chinese)
Thesis:
1. Hao-Jun
You. Sensory-Motor
interaction of the spinal cord dorsal horn neuron and spinal withdrawal
reflex in rats. Ph.D. Thesis, Department of Health Science and
Technology, Aalborg University, Denmark, 2003.
Abstracts:
1. Hao-Jun You, Lars Arendt-Nielsen.
Differences in
responsiveness of spinal dorsal horn neurons and simultaneously
recorded spinal
withdrawal reflexes in different concentrations of halothane
anesthetized
spinal rats. 11th World Congress on Pain, International
Association
for the Study of Pain (IASP), 21-26 August 2005, Sydney, Australia.
2005; 249,
No. 694-P300
2. Hao-Jun
You, Lars Arendt-Nielsen. Contralateral hypersensitized
wind-up
and after-discharge of spinal withdrawal reflex induced by unilateral
subcutaneous bee venom but not formalin injection and its central
mechanisms in
spinal anathesitized rats. 28th Annual Meeting of the
Scandinavian
Association for the Study of Pain (SASP), 19-22 May 2005, Oslo, Norway.
p65.
3. Hao-Jun You, Carsten Dahl Morch, Jun Chen, Lars Arendt-Nielsen. Differential role of peripheral glutamate receptor on bee venom induced spontaneous nociception ans sensitization. 10th World Congress on Pain, San Diego, USA, IASP Press, 2002, p271.
4. Hao-Jun You, Jun Chen, Lars Arendt-Nielsen,
Carsten
Dahl Nielsen.
Co-expression of wind-up in both dorsal horn WDR
unit and flexor single motor unit induced by cutaneous electrical
stimulation
in halothane-anesthetized rats. Chin. J. Neuroanatomy, 2001;17:Suppl.
p111.
5. Hao-Jun You, Bin Yuan, Jing-Shi Tang, Lars
Arendt-Nielsen.
Role of cerebral cortex in the inhibitory effect
of electro-acupuncture on the tonic pain response of spinal dorsal horn
neurons in rats. The 3rd EFIC Congress (Nice, France), 2000, p209.
6. Jun Chen, Hui-li Li, Hao-Jun You, Lars
Arendt-Nielsen.
Long-term hypersensitivity of spinal dorsal horn
neurons to heat and mechanical stimulation induced by subcutaneous bee
venom injection in anaesthetized rats and cats. The 3rd EFIC Congress
(Nice,
France), 2000, p208.
Updated: April. 29th, 2006